Medications · GLP-1
Zepbound Before Surgery
Zepbound is tirzepatide — the same molecule as Mounjaro — prescribed for weight loss. For surgery, the concern is the same as Ozempic and Wegovy: a slower-emptying stomach.
Quick answer
Why it matters
Like other GLP-1 medicines, Zepbound delays stomach emptying, so food can stay in the stomach longer than expected — raising aspiration risk under anesthesia.
Recent multi-society guidance moved away from a blanket 'stop it' rule toward identifying higher-risk patients (ongoing nausea, dose-increase phase) and managing them individually.
Because Zepbound is taken for weight loss, some patients skip mentioning it at the pre-op check — don't. It changes how your anesthesia team plans your day.
Do not stop without instruction
What to ask your doctor
- Should I take my usual Zepbound dose before surgery, or hold it?
- Should I follow a clear-liquid diet for 24 hours beforehand?
- Do my symptoms make me higher risk?
- Anything different because it's a weekly injection?
Red flags — call your team
Red flags — call your team
- Ongoing nausea, vomiting, or bloating
- You recently increased your dose
- You lost weight rapidly in recent weeks (mention it — it can change drug dosing)
References
- American Society of Anesthesiologists (ASA) & multi-society consensus on GLP-1 receptor agonists before anesthesia. asahq.org
Frequently asked questions
Do I stop Zepbound before surgery?
Not necessarily. Many patients can continue GLP-1/GIP medicines before elective surgery; higher-risk patients may follow a 24-hour clear-liquid diet or hold the dose. Tell your team and follow their advice.
Is Zepbound the same as Mounjaro for surgery purposes?
Yes — both are tirzepatide. The surgical guidance is identical; only the licensed use differs (Zepbound for weight loss, Mounjaro for type 2 diabetes).